PROCESS FOR PREPARATION OF PYRIDINE DERIVATIVES

摘要

The pyridine derivative, 3,5-dimethyl-4-methoxy-2-hydroxymethyl pyridine(I), is prepared by : (a) making pyridinon derivative(VIII) from pentenon derivative(IV); (b) making chloropyridine derivative(IX) from the reaction with POCl3 or PCl5; (c) making methoxy pyridine derivative(X) from the reaction with metal alkoxyde such as sodium alkoxyde or potassium alkoxyde; (d) hydrogenating under the catalyst of Pd/C and 1-20 kg/cm3 hydrogen pressure.