Ether lipid-nucleoside covalent conjugates

摘要

Ether lipid nucleoli covalent conjugates and derivatives thereof are disclosed, along with pharmaceutical compositions containing the same and methods of using the same to combat HIV-1 infections. Illustrative are 3'-Azido-3'-deoxythmidine-5'-monophosphate-D,L-3-octadecanamido-2-ethoxypropane and 3'-Azido-3'-deoxythymidine-5'-butyrate- gamma -N,N,N-trimethyl -ammonium- beta -(1-phospho-2-ethoxy-3-hexadecyloxypropane).