发明名称 |
Enzymatic acylation of 3-hydroxymethyl cephalosporins |
摘要 |
O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides esterase, a wheat germ lipase, an Aspergillus niger lipase, an orange peel acetylesterase or a Bacillus subtilis esterase. A preferred enzyme is the esterase from Rodosporidium toruloides ATCC 10657. The enzyme can be used while in whole cells or in soluble or inmobilized form.
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申请公布号 |
US5512454(A) |
申请公布日期 |
1996.04.30 |
申请号 |
US19940191304 |
申请日期 |
1994.02.03 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
USHER, JOHN J.;ROMANCIK, GUNA;POLITINO, MICHAEL;LOWE, DAVID A. |
分类号 |
C12P35/04;C12P35/00;C12R1/125;C12R1/645;C12R1/66;(IPC1-7):C12P35/04;C12P35/06;C12N9/20 |
主分类号 |
C12P35/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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