发明名称 |
Solid phase oligonucleotide synthesis using phospholane intermediates |
摘要 |
Methods and compounds are provided for solid phase synthesis of oligonucleotides and related polymers by condensing protected monomer-O-[1,3,2-dichalcogen-substituted-phospholane] synthons in the presence of a catalytic base. Compounds of the invention include 2-N-substituted-1,3,2-dichalcogen-substituted-phospholane precursors of the above synthons, the protected monomer-O-[1,3,2-dichalcogen-substituted-phospholane] synthons, and P-chiral oligonucleotides and related P-chiral polymers.
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申请公布号 |
US5512668(A) |
申请公布日期 |
1996.04.30 |
申请号 |
US19920826929 |
申请日期 |
1992.01.23 |
申请人 |
POLISH ACADEMY OF SCIENCES |
发明人 |
STEC, WOJCIECH J.;GRAJKOWSKI, ANDRZEJ;UZNANSKI, BOGDAN |
分类号 |
C07F9/6564;C07F9/6578;C07H19/10;C07H19/20;C07H21/00;C07H21/04;(IPC1-7):C07H21/02 |
主分类号 |
C07F9/6564 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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