Process for producing an insulin precursor in streptomyces
摘要
<p>A gene for a truncated proinsulin in which the insulin B chain is linked to the A chain only via Lys or Lys-Lys is coupled to the tendamistat gene, this gene construct is inserted into an expression vector, and the latter is used to transform a Streptomycetes host cell, with the result that the corresponding fusion protein is expressed and secreted. The fusion protein can easily be cleaved to give insulin precursors.</p>
申请公布号
GR3018738(T3)
申请公布日期
1996.04.30
申请号
GR19960400123T
申请日期
1996.01.19
申请人
HOECHST AKTIENGESELLSCHAFT
发明人
KOLLER, KLAUS-PETER, DR.;RIESS, GUENTHER, JOHANNES, DR.;UHLMANN, EUGEN, DR.;WALLMEIER, HOLGER, DR.