Novel compounds and salts thereof

摘要

Compounds of the formula I in which R denotes butyl, R1 denotes hydrogen, R2 denotes 3,4-dichlorobenzyl, 1-(4-chlorophenyl)ethyl or 1-(3,4-dichloro)phenethyl and R3 denotes hydrogen or R denotes diethoxymethyl, R1 denotes hydrogen and R2 denotes 2,6- or 3,5-dichlorobenzyl, pyrid-3-ylmethyl, 1-(4-methoxyphenyl)ethyl, 1-(4-chloro-3-iodophenyl)ethyl or 1-(3-chloro-4-iodophenyl)ethyl or R1 denotes hydroxyl and R2 denotes 3,4-dichlorobenzyl, 1-(3-chloro-4-iodophenyl)ethyl, 1-(4-chloro-3-iodophenyl)ethyl or 1-(3,4-dichlorophenyl)ethyl and R3 denotes hydrogen or R denotes cyclohexylmethyl, R1 denotes hydrogen and R2 denotes 3,5-dichlorobenzyl, quinolin-4-ylmethyl, 1-(3-chlorophenyl)ethyl, or 1-(3,4,5-trimethyoxyphenyl)ethyl or R1 denotes hydroxyl and R2 denotes 3,4-dimethylbenzyl, 3,4-methylenedioxybenzyl, 1-(3-chlorophenyl)ethyl, 1-(3,4-dichlorophenyl)ethyl, 1-(3-chloro-4-iodophenyl)ethyl, 1-(4-chloro-3-iodophenyl)ethyl, 1-(2,4-dimethoxyphenyl)ethyl, 1-(2,5-dimethoxyphenyl)ethyl, 1-(2,6-dimethoxyphenyl)ethyl, 1-(3,4-dimethoxyphenyl)ethyl, 1-(3,4-methylenedioxyphenyl)ethyl, 1-(3,5-dimethoxyphenyl)ethyl, 1-(3,4,5-trimethoxy)phenethyl-3-phenylprop-2-yl, 2-(3,4-dichlorophenyl)propyl 2-(3,4-dichlorophenyl)propyl, 3-(3,4-dichlorophenyl)prop-2-yl or 3-phenyl-3-hydroxyprop-2-yl and R3 denotes hydrogen or R denotes cyclohexylmethyl, R1 denotes hydrogen, R2 denotes 4-chlorobenzyl and R3 denotes methyl or R denotes cylohex-3-enylmethyl, R1 denotes (S)-hydroxyl, R2 denotes 1(S)- (3,4-dichlorophenyl)ethyl and R3 denotes hydrogen or R denotes benzyl, R1 denotes hydroxyl, R2 denotes alpha -cyclopropyl-3,4-dichlorobenzyl, 3,4,5-trimethoxybenzyl, 1-(3,5-dimethoxyphenyl)ethyl, 1-(3,4-dichlorophenyl)ethyl, 2-(3,4-dichlorophenyl)ethyl, 1-(3-chloro-4-iodophenyl)ethyl, 1-(3,4-dichlorophenyl)-2-hydroxyethyl, 2-(3,4-dichlorophenyl)-2-hydroxyethyl, 1-(2,4-dimethoxyphenyl)ethyl, 1-(2,5-dimethoxyphenyl)ethyl, 1-(2,6-dimethoxyphenyl)ethyl, 1-(3,4-dimethoxyphenyl)ethyl, 1-(3,4-methylenedioxyphenyl)ethyl, 1-(3,4,5-trimethoxyphenyl)ethyl, 3-phenylprop-2-yl, 3-phenyl- 3-hydroxyprop -2-yl, 1-, 2- or 3-(3,4-dichlorophenyl)propyl, 3-(3,4-dichlorophenyl)prop-2-yl, 3-(3,4-dichlorophenyl)-3-hydroxyprop-2-yl or 4-(3,4-dichlorophenyl)butyl and R3 denotes hydrogen, or R denotes 4-chlorobenzyl, 4-methylbenzyl, 4-methoxybenzyl or cyclohex-3-enylmethyl and R1, R2 and R3 represent hydrogen, and their salts have GABAB-antagonistic properties and can be used for the treatment of disorders responding to GABAB antagonists.