METHOD FOR TOPICAL INHIBITION OF THE METABOLIC ACTIVITY OF CYTOCHROME P-450

摘要

This invention relates to a method for the inhibition of the metabolic activity of cytochrome P450 enzymes by topical administration of a cytochrome P450 inhibitor. Particularly, this invention relates to a method for inhibition of the metabolic activity of cytochrome P450 in the lungs or nasal membranes of a patient by topical administration of a cytochrome P450 inhibitor by inhalation. The effect of the inhibition of cytochrome P450 activity is the increase in the localized concentration of administered or endogenous steroids normally metabolized by the cytochrome P450. This increased concentration of steroid results in the more effective treatment of inflammatory conditions of the lungs and nasal membranes.