发明名称 AMIDINE DERIVATIVES, METHOD FOR THEIR PRODUCTION, THEIR USING AS INHIBITORS OF NO-SYNTASE, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT
摘要 FIELD: organic chemistry, medicine. SUBSTANCE: desired amidine derivatives have formula I where Ris linear or branched C-alkyl group, C--alkenyl group, C-alkynyl group, C-cycloalkyl group or C-cycloalkyl C-alkyl group; Q is alkylene, alkenylene or alkynylene-group with 3-6 atoms being alternatively substituted by one or more C-alkyl groups; group having formula -(CH)X(CH)where p is number 2 or 3, q is integer 1 or 2 and X represents S(O), where x is 0,1 or 2, or O or NRwhere Ris hydrogen or C-alkyl, or group having formula -(CH)A)CHwhere r is 0,1 or 2, S is 0,1 or 2 and A represents 3-6 membered carbocycle or heterocycle ring which may be alternatively substituted by one or more suitable substituents (e.g. C-alkyl, C-alkoxy, hydroxy, halide, nitro, cyan, trifluoro-C-alkyl, amino, C-alkylamino or di- -C-alkylamino). EFFECT: produces novel compounds.
申请公布号 RU94031155(A) 申请公布日期 1996.04.20
申请号 RU19940031155 申请日期 1992.12.23
申请人 DZE VELKAM FAUNDEJSHN LIMITED 发明人 RICHARD MEHNSFILD BIMS;GAROL'D FREHNSIS KHODSON;RICHARD MAJKL DZHON PEHLMER
分类号 C12N9/99;A61K31/155;A61K31/195;A61K31/198;A61K31/275;A61P9/00;A61P19/02;A61P37/06;A61P43/00;C07C257/14;C07C257/16;C07C315/04;C07C317/50;C07C319/20;C07C323/58;C07C323/59 主分类号 C12N9/99
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