发明名称 |
Peptide inhibitors of farnesyl-protein transferase |
摘要 |
The present invention is directed to tetrapeptides which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to a method of treating cancer with tetrapeptide inhibitors of farnesyl protein transferase, as well as pharmaceutical formulations useful for this method of treatment. |
申请公布号 |
AU2574695(A) |
申请公布日期 |
1996.04.19 |
申请号 |
AU19950025746 |
申请日期 |
1995.06.05 |
申请人 |
MERCK & CO., INC.;ISTITUTO DI RECERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. |
发明人 |
JACKSON B GIBBS;ANDREW WALLACE;ANTONELLO PESSI |
分类号 |
A61K38/00;C07K5/107;C07K5/117 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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