发明名称 |
PROCESS FOR PREPARING 17-BETA-SUBSTITUTED-ANDROSTA-3,5-DIEN-3-CARBOXYLIC ACIDS |
摘要 |
The disclosed invention is a process for preparing 17-beta-substituted-androsta-3,5-dien-3-carboxylic acids from 3-halo-17-beta-substituted-androsta-3,5-dienes. The process may be performed in either of two ways: (1) the 3-halo compound is reacted with a phosphine, a metal catalyst, and a coupling reagent in a suitable organic solvent, followed by hydrolyzation of the intermediate to a 3-carboxylic acid; or (2) the 3-halo compound is reacted with a phosphine, a metal catalyst, a strong aqueous base, and a phase transfer catalyst to produce the 3-carboxylic acid.
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申请公布号 |
WO9611206(A1) |
申请公布日期 |
1996.04.18 |
申请号 |
WO1995US12710 |
申请日期 |
1995.10.04 |
申请人 |
SMITHKLINE BEECHAM CORPORATION;BAINE, NEIL, HOWARD;MCGUIRE, MICHAEL, ANTHONY;YU, MARVIN, SUNGWHAN |
发明人 |
BAINE, NEIL, HOWARD;MCGUIRE, MICHAEL, ANTHONY;YU, MARVIN, SUNGWHAN |
分类号 |
A61K31/56;A61K31/575;A61P43/00;C07J3/00;C07J7/00;C07J9/00;C07J31/00;C07J41/00;C07J43/00;C07J75/00;(IPC1-7):C07J3/00;C07J17/00 |
主分类号 |
A61K31/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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