发明名称 |
CDR-GRAFTED TYPE III ANTI-CEA HUMANIZED MOUSE MONOCLONAL ANTIBODIES |
摘要 |
A humanized monoclonal antibody, comprising the complementarity-determining regions of a parental murine Class III, anti-CEA monoclonal antibody engrafted to the framework regions of a heterologous antibody, wherein the humanized monoclonal antibody retains the binding specificity of, but is less immunogenic in a heterologous host than, the parental murine monoclonal antibody. A preferred murine Class III, anti-CEA monoclonal antibody is the MN-14 antibody and the preferred heterologous antibody is from a human. Also provided are DNA constructs and vectors for producing the humanized monoclonal antibodies, and diagnostic and therapeutic conjugates using same.
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申请公布号 |
WO9611013(A1) |
申请公布日期 |
1996.04.18 |
申请号 |
WO1995US11964 |
申请日期 |
1995.09.28 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
HANSEN, HANS, J.;ARMOUR, KATHRYN, L. |
分类号 |
C12N15/09;A61K35/12;A61K38/00;A61K39/395;A61K47/48;A61K51/00;A61P35/00;C07K16/30;C07K16/46;C12N5/10;C12N15/13;C12P21/08;C12R1/91;(IPC1-7):A61K35/16;A61K39/00;A61K39/44;C07K16/00;C07K16/28 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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