| 摘要 |
PCT No. PCT/GB94/00895 Sec. 371 Date Feb. 6, 1995 Sec. 102(e) Date Feb. 6, 1995 PCT Filed Apr. 27, 1994 PCT Pub. No. WO94/25434 PCT Pub. Date Nov. 10, 1994Peptidyl derivatives are disclosed that are orally active metalloproteinase inhibitors. The peptidyl derivatives have a selective gelatinase action, have a long duration of action, and are useful in the prophylaxis or treatment of diseases or disorders in which stromelysis, collagenase or gelatinase have a role, for example, in the treatment of cancer to control the development of tumor metastases. |
