| 摘要 |
The invention discloses generic compound (2) and its analog (6) and pharmaceutically acceptable salts and methods of using these compounds for therapeutically and prophylactically treating a patient for an illness consisting of the group of Pneumocystis carinii and Toxoplasmosis gondii <IMAGE> (2) <IMAGE> (6) In compound (2), X and Y may be the same or different and are selected from the group consisting of OH and NH2; Z is one of either nitrogen or carbon and Q is one of either nitrogen or carbon, but when Z equals nitrogen, Q does not equal nitrogen, and when Q equals nitrogen, Z does not equal nitrogen; A is selected from the group consisting of nitrogen, carbon and sulfur and B equals carbon when A is selected from the group consisting of sulfur, carbon and nitrogen, B equals nitrogen when A equals carbon and B equals sulfur when A equals carbon; 3 is one of either hydrogen or methyl except where Z is nitrogen wherein R3 is zero; R4 is one of either a hydrogen or a first lower alkyl group except when A equals sulfur wherein R4 is zero; R1 is selected from the group consisting of hydrogen, nitroso group, aldehyde, a second lower alkyl group except when B is equal to sulfur wherein R1 is zero; and R2 is selected from the group consisting alkyl, dialkyl and trialkyl groups, alkylaryl, diaryl and triaryl groups, substituted aryl, diaryl and triaryl groups, an alkoxy, substituted alkoxy and halogen.
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