| 摘要 |
PCT No. PCT/US93/00880 Sec. 371 Date Aug. 16, 1994 Sec. 102(e) Date Aug. 16, 1994 PCT Filed Feb. 3, 1993 PCT Pub. No. WO93/17019 PCT Pub. Date Sep. 2, 1993.This invention relates to 5-chloro-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acid-octahydro-3-hydroxy-2,6-methano-2H-quinolizin-8-yl ester (I), a novel 5-HT3-receptor antagonist, its method of preparation, and to its end-use application in the treatment or radio- and chemo-therapeutically-induced nausea and vomiting, in the treatment or pain associated with migraine, in the treatment of cognitive disorders, in treating hallucinatory endogenous psychoses or the type manifested in patients suffering from schizophrenia and mania, for irritable bowel syndrome, and to combat drug abuse.
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