发明名称 |
Optically active 1-phenyl-2-substituted propane derivatives and methods of producing the same |
摘要 |
An (S)-1-phenyl-2-substituted propane derivative shown by the following formula (I) <IMAGE> (I) wherein R1 and R2 represent a lower alkyl group, etc., or R1 and R2 may form together an alkylene group, etc.; R3, R4 and R5 represent a hydrogen atom, etc.; and X represents a hydroxyl group which may be protected with a protective group, or a halogen atom etc., can readily be produced (i) by permitting a microorganism belonging to the genus Torulaspora, the genus Candida, the genus Pichia or the like to act on a phenylacetone derivative and asymmetrically reducing the compound, or (ii) by sterically inverting an (R)-enantiomer. (R,R)-1-phenyl-2-[(2-phenyl-1-methylethyl)amino]ethanol derivative having a high optical purity can easily be obtained from the compound of the formula (I). The ethanol derivative is useful as an anti-obesity agent and the like.
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申请公布号 |
US5508461(A) |
申请公布日期 |
1996.04.16 |
申请号 |
US19940252994 |
申请日期 |
1994.06.02 |
申请人 |
DAICEL CHEMICAL INDUSTRIES, LTD. |
发明人 |
ITO, MICHIO;YAMASAKI, NORITSUGU;KOBAYASHI, YOSHINORI;IKURA, KIYOSHI |
分类号 |
C07C39/11;C07C43/23;C07C213/02;C07C213/08;C07C217/60;C07C309/66;C07C309/73;C12P7/22;C12P17/06;(IPC1-7):C07C309/73;C07C43/205;C07C39/08 |
主分类号 |
C07C39/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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