发明名称 |
PERFLUORO-T-BUTYL ENTHALTENDE VERBINDUNGEN ZUR VERWENDUNG IN FLUOR-19-NMR UND/ODER MRI |
摘要 |
Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety, <IMAGE> is an excellent reported group for fluorine-19 NMR/MRI. It is a source of nine magnetically equivalent fluorine nuclei which generate a single intense resonance for each detection in spectroscopy or imaging. This signal is a sharp singlet, not split by neighboring nuclei or spread over a wide frequency range and eliminates any change of ghost images which might arise from multiple resonances. These spectral properties ensure a maximum signal-to-noise ratio (S/N) for readily detecting this moiety. The foregoing allows either reduction in the concentration of the derivatized compound, ability to use MRI instruments with lower field strengths, a reduction in imaging times, or a combination of the foregoing as a result of this moiety producing a single, sharp, intense resonance. Additionally, the PFTB moiety-containing compounds may be utilized to determine oxygen concentration in aqueous solutions present in animate and inanimate objects. |
申请公布号 |
AT136223(T) |
申请公布日期 |
1996.04.15 |
申请号 |
AT19900912277T |
申请日期 |
1990.07.19 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;TOWSON STATE UNIVERSITY |
发明人 |
ROGERS, WALTER, JOHN, JR.;EVERETT, THOMAS, STEPHEN |
分类号 |
A61K49/00;A61K49/06;(IPC1-7):A61K49/00 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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