Compounds containing a fused bicycle ring and processes therefor

摘要

Compounds of the formula <IMAGE> wherein X is O or S-(O)t; n is one or two; m is zero or one; Y is CH2, O, or S-(O)t provided that Y is O or S-(O)t only when m is one; and A is <IMAGE> are dual inhibitors of NEP and ACE. Compounds wherein A is <IMAGE> are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.