PROCESS FOR PRODUCING ANTHRACYCLINES AND INTERMEDIATES THEREOF

摘要

The present invention pertains to a process for producing anthracyclines and intermediates thereof by expressing in a foreign Streptomyces host a DNA fragment relating to the biosynthetic pathway of anthracyclines and, if desired, the intermediates obtained are converted to anthracyclines or aglycones thereof using e.g. non-producing Streptomyces mutant strains.