NUCLEIC ACID ENCODING MUTANT MATRIX PROTEINS USEFUL FOR ATTENUATION OR ENHANCEMENT OF INFLUENZA A VIRUS

摘要

Attenuated or enhanced influenza viruses (IAV's) are provided using RNA or DNA encoding mutated matrix proteins (MMPs). Replacing MP nsRNA with nsRNA encoding attenuating MP (AMP) or enhancing MP (EMP) gives attenuated or enhanced IAVs, respectively. Also provided are methods of making and using AMP or EMP DNA or RNA for attenuating or enhancing IAV's.