| 摘要 |
PURPOSE: To obtain an antiretroviral agent capable of effectively inhibiting HIV infection and the spread thereof owing to its excellent cell membrane fusion blocking action, containing, as active ingredient, bryostatin 10 derived from Terebellidae. CONSTITUTION: This antiretroviral agent contains, as active ingredient, a compound of the formula. This compound is obtained, for example, by the following process: an extract obtained by subjecting Terebellidae to extraction with dichloromethane is fractionated with a Sephadex LH-20 column to obtain a fraction and residues; these are screened with sea urchin fertilized egg cleavage inhibitory action as indicator to obtain an active fraction, which is then further fractionated with flush chromatography to obtain a fraction, which is then screened again with sea urchin fertilized egg cleavage inhibitory action as indicator to obtain an active fraction, which is, in turn, fractionated with HPLC. The dose of this agent (in terms of the active ingredient) is pref. 0.01-100mg/kg b.w. a day per adult. |
