| 摘要 |
Pyranose derivs. of formula (I) and their optical and geometric isomers and acid-addn. salts are new: A =OR6 and B=CH2X, or A+B forms an oxirane, 2,2-dimethyl-1,3-dioxolane or 1,3-dioxolan-2-one ring; R1 = -C(Y)(R7)-CH(Z)(R8) and R2 = H, OH or OR9; or R1 = O(CH2)n-C(Y)(R7)-CH(Z)(R8) and R2 = H; or R1 = H and R2 = -C(Y)(R7)-CH(Z)(R8); Y and Z = H or Y+Z = a bond or O; R3 = H, 1-6C alkyl, benzyl, benzoyl, formyl, 1-6C acyl, allyl or carbamoyl; R4 = OH, 1-6C alkoxy, carbamoyloxy, 4-R9-1-piperazinylcarbonyloxy or 1-imidazolylcarbonyloxy; R5 = H; or R4+R5 = O; R6-R8 = H or 1-6C alkyl opt. substd. by phenyl; R9 = H, 1-6C alkyl, 1-6C acyl, 2-6C alkoxycarbonyl, benzyl, or carbamoyl; X = OH, halogen, phenylsulphonyloxy or 1-6C alkylsulphonyloxy; carbamoyl and carbamoyloxy gps. are opt. mono- or disubstd. by 1-6C alkyl, 1-6C acyl, benzoyl, phenyl, naphthyl and/or amino opt. mono- or disubstd. by 1-6C alkyl; alkyl, alkoxy, alkoxycarbonyl, acyl, benzyl, benzoyl, phenyl and naphthyl gps. are opt. substd. by OH, halogen trihalomethyl, amino, alkylamino, dialkylamino, 1-6C alkoxy, 2-6C alkoxycarbonyl, and/or 1-6C acyl; alkylsulphonyloxy and phenylsulphonyloxy gps. are opt. substd. by 1-6C alkyl. |
