发明名称 Polyiodinated compounds, preparation and use thereof in x-ray radiology
摘要 PCT No. PCT/FR95/01212 Sec. 371 Date Mar. 21, 1997 Sec. 102(e) Date Mar. 21, 1997 PCT Filed Sep. 20, 1995 PCT Pub. No. WO96/09280 PCT Pub. Date Mar. 28, 1996The invention relates to compounds of formula: <IMAGE> <IMAGE> in which Ti, Vi, T'i and V'i with i=0, 1 or 2, represent O, COND or NDCO, D being H, alkyl or (poly)hydroxyalkyl; Qi and Q'i with i=0, 1 or 2, represent alkylene or (poly)hydroxyalkylene; Ari and Ar'i with i=1 or 2, represent <IMAGE> in which R, R3, R4 are COOH and R', R'3, R'4 are CONR'1R'2 or N(R'1)COR'2, R' and R'2 being H, alkyl or (poly)hydroxyalkyl such that R'1 and R'2 together comprise at least 4 hydroxyl groups, or Ri and R'i with i=nothing, 3 or 4 represent CONR'1R'2 or N(R'1)COR'2, R'1 and R'2 together comprising at least 6 hydroxyl groups, or else Ri and R'i with i=3 or 4 represent T-Q-V-Ar, T, Q and V being as defined above for Ti, Qi and Vi and Ar having formula II, and A is a biocompatible radical of molecular weight less than 1200 having two valences such as to give with To and T'o an amide or ether group.
申请公布号 AU3524195(A) 申请公布日期 1996.04.09
申请号 AU19950035241 申请日期 1995.09.20
申请人 GUERBET S.A. 发明人 GAEL LE LEM;DOMINIQUE MEYER
分类号 A61K49/04;C07C231/02;C07C237/46 主分类号 A61K49/04
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