GLYCATE POLY-L-LYSINE DERIVED FROM POLYLYSINE AND METHYLGLUCOSE

摘要

PURPOSE: To obtain a new glycate poly-L-lysine having active oxygen producing capability and nucleic acid cutting action in high efficiency and yield by reactingε-poly-L-lysine, etc., with a specific monomer under physiological condition. CONSTITUTION: The objective glycate poly-L-lysine is produced by incubatingε-poly-L-lysine of formula I orα-poly-L-lysine of formula II and 3-O-methyl-D- glucose of formula III e.g. in a 0.1M phosphate buffer solution of pH7.2 in the presence of 0.1% gentamicin as a preservative at 37 deg.C for 7 days.