ISOBENZOFURANONE COMPOUND AND LIPID LOWERING AGENT

摘要

An isobenzofuranone compound represented by general formula (I) or a pharmaceutically acceptable salt thereof and a novel lipid lowering agent based on the effect of promoting the incorporation of LDL, wherein R<1> represents C1-C5 alkoxy; R<2> represents hydrogen, hydroxyl, C1-C18 alkoxy, C3-C6 cycloalkoxy, C2-C6 alkoxyalkoxy, C3-C7 alkoxyalkoxyalkoxy, C2-C6 alkylthioalkoxy, C7-C9 phenylalkoxy, C3-C5 alkenyloxy, C3-C5 alkynyloxy, C3-C6 alkanoyloxyalkoxy, C2-C6 alkanoyloxy, cyclic amine-substituted alkoxy, trifluoromethylsulfonyloxy, phenoxy or nitrophenoxy; and R<3> represents (a), (b) or (c).