ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EMESIS

摘要

A method for the treatment of emesis using a therapeutically effective amount of an endothelin receptor antagonist. This invention also concerns the use of an endothelin antagonist for the treatment of any endothelin-induced form of emesis, including acute, delayed, post-operative, last-phase, and anticipatory emesis, for example, induced by chemotherapy, radiation, toxins, pregnancy, vestibular disorder, motion, post-operative sickness, surgery, gastrointestinal obstruction, reduced gastrointestinal motility, visceral pain, migraine, opiod analgesics and variations in intercranial pressure (except quaternary salts). Additionally, this invention is concerned with a pharmaceutical composition for the treatment of emesis comprising: an endothelin antagonist in combination with an NK1 antagonist and/or a 5HT3 antagonist.