COMPOUNDS AND METHODS FOR IDENTIFYING ACTIVATED PLATELETS

摘要

The invention is directed to a series of novel compounds, and their pharmaceutically acceptable salts, of formula (I) wherein R is C0/6 alkyl substituted with R<5> or a mono or polycyclic aromatic or heteroaromatic system comprised of 5 or 6-membered aromatic or heteroaromatic rings that are either unsubstituted or substituted with one or more of R<1> and R<2>; R<1> and R<2> are independently C1-6 alkyl, carboxyl, hydroxyl, azido, nitro, amino, C1-6 alkylamino, C1-6 dialkylamino, arylamino, aryl C1-6 alkylamino, hydroxysulfonyl or arylazo; aryl is a phenyl or naphthyl ring which is unsubstituted or substituted with one or more of R<3> and R<4>; R<3> and R<4> are independently C1-6 alkyl, azido, nitro, amino, C1-6 dialkylamino or hydroxysulfonyl; R<5> is (II) or (III) provided that when R is an unsubstituted monocyclic ring, the monocyclic ring is not phenyl or pyridyl. Such compounds are useful as fluorescent probes for identifying antiplatelet agents which selectively bind to activated platelets.