| 摘要 |
The invention relates to particulate contrast agents, especially contrast agents for MR imaging, having a metal oxide, preferably superparamagnetic iron oxide core provided with a low coating density of a polyelectrolyte coating agent selected from structural polysaccharides and synthetic polymers, especially polyaminoacids. Unlike conventional coated particulates, the new particles have reduced or no effect on cardiovascular parameters, platelet depletion, complement activation and blood coagulation.
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