TRIAZOLE DERIVATIVES, METHOD OF PREPARATION THEREOF, INTERMEDIATE PRODUCTS OF THESE METHODS, PHARMACEUTICAL AND ANTIFUNGAL AGENT AND APPLICATION OF THESE COMPOUNDS

摘要

Triazole derivatives of the general formula 1, in which R is a phenyl group substituated by 1 to 3 substituents, whereby every substituent is independently chosen from the group, which includes halogens, -CF3 and -OCF3 group, R1C1-C4 alkyle group, R2 carbon atom or C1-C4 alkyle group, X CH group or nitrogen atom and Y fluorine or chlorine. Into the range also belong processes of preparation of these compounds and intermediate products of this process of general formulas IV, VI and XI, wherein mentioned symbols have an above listed meaning and Z2 and Z3 are independently hydrogen and by reduction removable groups, whereby these substituents cannot be both carbon atoms. Into the range also belong pharmaceutical agents which contain mentioned triazole derivatives and next the use of these compounds for preparing of the antifugal effect medicine.