3-(4-PHENYL-1-PIPERAZINYL)-2-HYDROXY-1-PROPYLESTERS OF ALKOXYPHENYL-CARBAMIC ACIDS AND METHOD OF PREPARATION THEREOF

摘要

Compounds of general formula 1, where R means alkoxyle with 1 to 3 carbon atoms as well as their inorganic and organic acids salts are prepared by reaction of 3-bromo-2-hydroxy-1- -propylester of alkoxyphenylcarbamic acid with N-phenylpiperazine in an aqueous medium at ambient temperature, and/or by reaction of 2,3-epoxy-1-propylester of alkoxyphenylcarbamic acid with N-phenylpiperazine in an alkanol medium at boiling point of the reaction mixture. These compounds display antidisrhytmic activity.