| 摘要 |
Treatment of functional bowel disorders involves admin. of 2-methyl-4-(4-methyl-1-piperazinyl) -10H-thieno(2,3-6) (1,5)benzodiazepine (I) or its acid addn. salt. In an example, a tablet formulation, contg. 5.0 mg (I), 0.9 mg magnesium stearate, 75.0 mg microcrystalline cellulose, 15.0 mg povidone and 204.1 mg directly compressible starch, was prepd. by granulating the active agent with the diluent, disintegrant and binder then compressing. (I) displaced 3H-spiperone from 5-HT2B receptor binding sites in the rat frontal cortex at low nanomolar concns. |
