发明名称 |
2H-3,4-tetrahydroquinazoline-2-one and 2H-3,4-tetrahydroquinalozine-2,4-dione derivatives, pharmaceutical compositions and methods of treatment |
摘要 |
The cyclic amide derivative is defined by the formula (I) or a salt thereof: R1-(CH2)n-Z in which R1 is a group derived from a cyclic amide compound, substituted or unsubstituted, n is zero or an integer of 1 to 10 and Z is <IMAGE> (1) or <IMAGE> (2) R2 being an aryl, a substituted aryl, a cycloalkyl or a heterocyclic group, m being an integer of 1 to 6, R3 being hydrogen or a lower alkyl, R4 being an aryl or a substituted aryl, a cycloalkyl or a heterocyclic group, p being an integer of 1 to 6, provided that the cyclic amide compound is quinazoline-on or quinazoline-dion, R2 and R4 are neither aryl nor substituted aryl. The cyclic amide compound is pharmacologically effective to prevent and treat diseases due to insufficiency of the central choline functions.
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申请公布号 |
US5504088(A) |
申请公布日期 |
1996.04.02 |
申请号 |
US19930165490 |
申请日期 |
1993.12.13 |
申请人 |
EISAI CO., LTD. |
发明人 |
SUGIMOTO, HACHIRO;YONAGA, MASAHIRO;KARIBE, NORIO;IIMURA, YOUICHI;NAGATO, SATOSHI;SASAKI, ATSUSHI;YAMANISHI, YOSHIHARU;OGURA, HIROO;KOSASA, TAKASHI;UCHIKOSHI, KUMI;YAMATSU, KIYOMI |
分类号 |
A61K31/40;A61K31/00;A61K31/395;A61K31/42;A61K31/423;A61K31/4427;A61K31/443;A61K31/4433;A61K31/445;A61K31/454;A61K31/495;A61K31/496;A61K31/4985;A61K31/505;A61K31/517;A61K31/519;A61K31/535;A61K31/536;A61K31/5365;A61K31/5377;A61K31/55;A61P9/00;A61P25/00;A61P25/02;A61P25/28;A61P43/00;C07D207/16;C07D263/58;C07D265/18;C07D265/26;C07D401/04;C07D401/06;C07D401/14;C07D405/14;C07D409/14;C07D413/06;C07D413/12;C07D413/14;C07D471/04;C07D475/02;C07D487/04;C07D495/04;C07D498/04;C12N9/99;(IPC1-7):A61K31/505;C07D239/80;C07D239/96;C07D405/12 |
主分类号 |
A61K31/40 |
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