发明名称 Mechanism based inhibitors of DNA methyltransferase
摘要 PCT No. PCT/US91/07622 Sec. 371 Date Jun. 22, 1992 Sec. 102(e) Date Jun. 22, 1992 PCT Filed Oct. 21, 1991 PCT Pub. No. WO92/06985 PCT Pub. Date Apr. 30, 1992.Novel synthetic oligomers of unique three-dimensional structure comprising homologous and heterologous blocks, some of which may self-associate are described. Also disclosed is a synthetic oligonucleotide that includes 5-fluorocytosine residues at positions corresponding to methylation sites of DNA-cytosine methyltransferase and a method for preparing such a molecule.
申请公布号 US5503975(A) 申请公布日期 1996.04.02
申请号 US19920861899 申请日期 1992.06.22
申请人 CITY OF HOPE 发明人 SMITH, STEVEN S.;KAPLAN, BRUCE E.
分类号 C07H21/00;C07K1/107;C07K14/245;C12N9/10;C12N15/10;C12N15/11;C12P19/34;C12Q1/68;(IPC1-7):C12Q1/68;C12Q1/00 主分类号 C07H21/00
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