发明名称 |
Recombinant mutants for inducing specific immune responses |
摘要 |
A recombinant plasmid comprises the cyaC and the cyaA genes of Bordetella which directs the expression of Bordetella, adenylate cyclase in a transformed host cell. A recombinant DNA molecule can comprise the Bordetella cyaA gene containing at least one insertion of a heterologous DNA sequence at at least one permissive site. In addition, a recombinant Bordetella adenylate cyclase comprises a heterologous epitope at a permissive site. Methods of inducing a specific B cell, helper T cell, and CTL cell immune response are provided.
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申请公布号 |
US5503829(A) |
申请公布日期 |
1996.04.02 |
申请号 |
US19940336087 |
申请日期 |
1994.11.07 |
申请人 |
INSTITUT PASTEUR |
发明人 |
LADANT, DANIEL;LECLERC, CLAUDE;SEBO, PETER;ULLMANN, AGNES |
分类号 |
A61K39/00;C07K14/005;C07K14/105;C07K14/11;C07K14/16;C07K14/495;C07K14/54;C07K14/55;C12N9/88;C12N15/31;(IPC1-7):A61K39/10;A61K39/295;C07K14/235;C07K17/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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