Controlled release pharmaceutical formulation prodn. - by (electro)mechanical treatment of mixt. of drug and excipient opt. followed by pelletising, for delayed or rapid release

摘要

Prepn. of controlled release pharmaceutical formulations comprises: (i) subjecting a mixt. of excipient(s) (I) and active ingredient(s) (II) to mechanical or electromechanical action for a predetermined time (pref. 0.1-20 secs.) and within a wide range of frequencies (pref. between 1 kHz and 2MHz) film; and opt., (ii) pelletising the prod. to give pellets having dia. 2.5mm or less which retain the same controlled release properties. Also claimed are formulations obtd. by step (i) (for oral, topical or parenteral admin., pref. of dia. 2-15mm as tablets or matrix or size 4mm to 30cm. as a film, and of thickness 0.1-10mm); and powder or granulate formulations obtd. by steps (i) and (ii) (suitable for direct use or insertion in hard gelatin capsules).