发明名称 |
Modification of DNA and oligonucleotides using metal complexes of polyaza ligands |
摘要 |
A process is provided for oxidatively modifying nucleic acids containing a target nucleotide. The nucleic acid is contacted with a polyaza metal complex in the presence of an oxidizing agent so that the nucleic acid is modified at or near the target nucleotide. Also provided are a kit for carrying out the process and a method for treating neoplastic growth by administering to a subject having neoplastic growth, an effective amount of a polyaza metal complex which is capable of modifying DNA.
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申请公布号 |
US5504075(A) |
申请公布日期 |
1996.04.02 |
申请号 |
US19930128308 |
申请日期 |
1993.09.28 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK |
发明人 |
BURROWS, CYNTHIA J.;ROKITA, STEVEN E.;CHEN, XIAOYING |
分类号 |
C12Q1/68;(IPC1-7):A01N55/02 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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