| 摘要 |
Carbamoyloxypropylamine or carbamoyloxyethylamine compounds of formula (I), wherein A represents CH2 or a bond, R1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or phenyl; and R2 is alkyl, alkenyl, alkynyl, cycloalkyl or phenyl; or R1 and R2 together form a ring; R3 and R4 are hydrogen, alkyl, alkenyl, alkynyl, halogenated alkyl, cycloalkyl, phenyl, or phenylalkyl or R3 and R4 together form a spirojoined C4-7 carbocycle; or when R1 and R2 are not linked, R3 and R2 may form ring; R5 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, or phenylalkyl or together with R2 form a ring; or R5 together with R4 form a ring; R6 and R7 are hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, phenyl or phenylalkyl; or R6 and R7 together form a ring; are ligands at the central nicotine acetylcholine receptors (nAChRs). The compounds are useful in the treatment of cognitive, neurological or mental disorders in which nAChR dysfunction is involved. |
