发明名称 |
USE OF A NON-MAMMALIAN DNA VIRUS TO EXPRESS AN EXOGENOUS GENE IN A MAMMALIAN CELL |
摘要 |
Disclosed is a method of expressing an exogenous gene in a mammalian cell, involving infecting the cell with a non-mammalian virus, such as a baculovirus, whose genome carries an exogenous gene, and growing the cell under conditions such that the gene is expressed. Exogenous genes are delivered to mammalian cells by use of a transfer vector such as that described in the figure. Also disclosed is a method of treating a gene deficiency disorder in a mammal by providing to a cell a therapeutically effective amount of a virus whose genome carries an exogenous gene and growing the cell under conditions such that the exogenous gene is expressed in the mammal.
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申请公布号 |
WO9609074(A1) |
申请公布日期 |
1996.03.28 |
申请号 |
WO1995US11456 |
申请日期 |
1995.09.08 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
BOYCE, FREDERICK, M. |
分类号 |
C12N15/09;A61K31/70;A61K35/76;A61K38/00;A61K38/28;A61K38/43;A61K38/44;A61K38/45;A61K38/46;A61K38/55;A61K48/00;A61P3/00;A61P3/06;A61P3/08;A61P7/00;A61P19/06;A61P31/12;C12N5/00;C12N5/10;C12N15/866;C12R1/91;(IPC1-7):A61K48/00;A61K49/00;C12N15/00;C12N15/10;C12N15/86 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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