TREATMENT OF PLASMODIUM

摘要

Plasmodium is shown to have an inhibition sensitive sphingomyelin synthase activity necessary for ring and early trophozoite maturation. Inhibitors can therefore be used to treat malarial infection which can differentiate between inhibition sensitive Plasmodium sphingomyelin synthase and mammalian synthase. Inhibitors of interest include 1-phenyl-3-morpholino-2-acylated-aminopropanol-1. The development of this invention was supported at least in part under NIH grant R01 A126670, BRSG RR05353, and by the McArthur foundation. The government may have rights in this invention.