摘要 |
The present invention provides a pharmaceutical composition comprising an estramustine derivative and a cyclodextrin, particularly in the manufacture of a medicament suitable for the oral administration of an estramustine derivative to a patient suffering from a tumor. Estramustine derivatives according to the invention are, for example, compounds of general formula (I) wherein R is (a) or (b) in which R1 is C1-C4 alkyl and n is 0, 1 or 2, and the pharmaceutically acceptable salts thereof. |
申请人 |
PHARMACIA AB;MARTINI, ALESSANDRO;MACCARI, GIUSEPPE;MUGGETTI, LORENA;COLOMBO, GIUSEPPE;BUZZI, GIOVANNI |
发明人 |
MARTINI, ALESSANDRO;MACCARI, GIUSEPPE;MUGGETTI, LORENA;COLOMBO, GIUSEPPE;BUZZI, GIOVANNI |