NOVEL ANTI-VH3-15 REAGENTS, VH3-15 POLYPEPTIDES, CELL SURFACE ANTIGENS, AND METHODS FOR THEIR DETECTION AND USE

摘要

The present invention provides novel anti-VH3-15 idiotypic antibody materials and hybridomas producing this antibody material. Also provided in the present invention are VH3-15 autoantibodies recognized by anti-VH3-15 idiotypic antibody material and the cell surface antigens which bind VH3-15 autoantibody. The anti-VH3-15 idiotypic antibody material, VH3-15 autoantibodies and cell surface antigens of the present invention can be used in methods for detecting, isolating and purifying VH3-15 polypeptides and in diagnostic assays for IBD and infection by Campylobacter jejuni. Nucleic acid molecules encoding anti-VH3-15 antibody material, VH3-15 autoantibody and cell surface antigens, as well as methods for their use are also provided.