发明名称 |
SINTESI QUANTITATIVA DELL'ACIDO 3-(L-PIROGLUTAMIL)-L-TIAZOLIDIN-4- CARBOSSILICO E SUOI DERIVATI |
摘要 |
<p>3-(L-Pyroglutamyl)-L-thiazolidine-4-carboxylic acid and the derivatives thereof are prepared in quantitative yields by a condensation process between L-pyroglutamic acid or substitution products thereof in the presence of an aliphatic or aromatic hydrocarbon solvent, or of chlorinated solvents in the presence of dicyclohexylcarbodiimide or similar condensing agents, or by condensation of L-pyroglutamic acid reactive derivatives with thiazolidine-4-carboxylic acid derivatives. The hydrolysis of the protective groups of thiazolidine-4-carboxylic acid is carried out by phase transfer catalysts in quantitative yields.</p> |
申请公布号 |
ITMI941955(A1) |
申请公布日期 |
1996.03.28 |
申请号 |
IT1994MI01955 |
申请日期 |
1994.09.27 |
申请人 |
POLI INDUSTRIA CHIMICA S.P.A. |
发明人 |
BOCCHIOLA GIANETTORE;MAGNI AMBROGIO;POLI STEFANO |
分类号 |
A61K38/00;C07D;C07K5/078 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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