RACEMISATION AND ASYMMETRIC TRANSFORMATION PROCESSES USED IN THE MANUFACTURE OF LEVOBUPIVACAINE AND ANALOGUES THEREOF

摘要

A process for the racemisation of an optically-enriched piperidine-2-carboxanilide compound, comprises heating the compound in the presence of an alkanoic or arylalkanoic acid. A process for the asymmetric transformation of such a compound comprises heating the compound in the presence of an acid as defined above, a chiral acid resolving agent and an inert cosolvent.