IMPROVEMENTS IN SENSITIVITY AND SELECTIVITY OF ION CHANNEL MEMBRANE BIOSENSORS

摘要

PCT No. PCT/AU89/00352 Sec. 371 Date Apr. 18, 1991 Sec. 102(e) Date Apr. 18, 1991 PCT Filed Aug. 17, 1989 PCT Pub. No. WO90/02327 PCT Pub. Date Mar. 8, 1990.The present invention provides a biosensor comprising at least one lipid membrane, each membrane including at least one gated ion channel. The membranes comprise a closely packed array of self-assembly amphophilic molecules and the gated ion channel has a conductance which is dependent upon an electric field applied across the membrane. The biosensor of the present invention may comprise a plurality of discrete membranes each including at least one gated ion channel. The conductance of each of the membranes is measurable independently of the conductance of the other membranes.