发明名称 |
Process for optically resolving 2-(3-benzoylphenyl) propionic acid |
摘要 |
<p>Provided is a process for separating (S)- or (R)-2-(3-benzoylphenyl)propionic acid from a mixture of (S)- and (R)-2-(3-benzoylphenyl)propionic acid, which comprises (1) reacting the mixture of (S)- and (R)-2-(3-benzoylphenyl)propionic acid with (S)- or (R)-3-methyl-2-phenylbutylamine in a suitable solvent to form a diastereomer salt of (S)-2-(3-benzoylphenyl)propionic acid with (S)-3-methyl-2-phenylbutylamine or a diastereomer salt of (R)-2-(3-benzoylphenyl)propionic acid with (R)-3-methyl-2-phenylbutylamine; (2) separating the diastereomer salt from the reaction mixture; and (3) liberating the separated diastereomer salt to give (S)- or (R)-2-(3-benzoylphenyl)propionic acid. According to the present process, it is possible to obtain optically active (S)- or (R)-2-(3-benzoylphenyl)propionic acid having 99% or more of high optical purity in a high yield. Thus, the present process is a practical and efficient process which can simplify purification steps and can be applied for an industrial production process.</p> |
申请公布号 |
EP0703212(A1) |
申请公布日期 |
1996.03.27 |
申请号 |
EP19950104740 |
申请日期 |
1995.03.30 |
申请人 |
NAGASE & COMPANY, LTD. |
发明人 |
NOHIRA, HIROYUKI;SAIJO, SHIGEYA;MORIWAKI, MASAFUMI;KAMIYAMA, SHUNJI;TOYODA, KAZUTOSHI;MATSUMOTO, JUN;MARUO, KOHICHI;FUJIMOTO, TAIZO |
分类号 |
C07B57/00;C07C51/487;C07C57/38;(IPC1-7):C07C51/487;C07C59/84 |
主分类号 |
C07B57/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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