| 发明名称 |
SPIRO (2H-1-BENZOPYRAN-2, 4' PIPERIDINE) CLASS III ANTIARRHYTHMICS. |
| 摘要 |
PCT No. PCT/US94/02097 Sec. 371 Date Nov. 2, 1995 Sec. 102(e) Date Nov. 2, 1995 PCT Filed Feb. 10, 1994 PCT Pub. No. WO94/18204 PCT Pub. Date Aug. 18, 1994A series of novel spirocycles of general structural formula: <IMAGE> or a pharmaceutically acceptable salt, hydrate or crystal form thereof are presented, wherein R1=H3CSO2NH-, H3CO-, alkylSO2-, alkylCONH-, NO2-; R2=H, -OCH3; R3 and R4 taken together are =O, or R3 is H and R4 is OH; R5=R6 taken together are -CH2-CH2-, =CH2; R7 is <IMAGE>gents and positive inotropic or cardiotonic agents. |
| 申请公布号 |
EP0683782(A4) |
申请公布日期 |
1996.03.27 |
| 申请号 |
EP19940909817 |
申请日期 |
1994.02.10 |
| 申请人 |
MERCK & CO. INC. |
发明人 |
BALDWIN, JOHN, J.;CLAREMON, DAVID, A.;ELLIOTT, JASON, M.;PONTICELLO, GERALD, S.;REMY, DAVID, C.;SELNICK, HAROLD, G. |
| 分类号 |
A61K31/445;A61P9/06;C07D491/10;C07D491/107 |
主分类号 |
A61K31/445 |
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