发明名称 |
Fremgangsmåte for fjerning av pertussisendotoksin og fremgangsmåte for fremstilling av pertussistoksoid |
摘要 |
The present invention provides a clear and efficient pertussis endotoxin-removing method characterized in that a fluid containing the antiinfective fraction and endotoxin of strains of phase I Bordetella pertussis is supplied with calcium ion in the presence of excess phosphate ion prior to zonal centrifugation and also a pertussis toxoid whose endotoxin content per 10 mu g of proteinic nitrogen is not more than 0.5 ng and its production method. |
申请公布号 |
NO178423(C) |
申请公布日期 |
1996.03.27 |
申请号 |
NO19880002208 |
申请日期 |
1988.05.20 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES LTD |
发明人 |
FUJITA, ISAO;WATANABE, HIDEO;MIYAMOTO, MASATOSHI |
分类号 |
A61K39/10;(IPC1-7):A61K39/10 |
主分类号 |
A61K39/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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