| 摘要 |
PURPOSE: To obtain an azetidinone compound using a not expensive raw material useful as an intermediate of a compound having an antimicrobial activity with easy handling and operation by reacting individually specific azetidinone derivative and an imide compound in the presence of a specific metallic compound and a base. CONSTITUTION: This aimed compound expressed by formula I (R is H or a removable protecting group; R<1> is a (protected) OH or a (substituted) alkyl; R<2> is a (substituted) alkyl; R<3> and R<4> are each a (substituted) alkyl or a (substituted) aryl; X is O or S) (e.g. N- (R)-2-[(3S,4R)-3-[(R)-1-t- butyldimethylsilyloxyethyl]-2-oxoazetidin-4-yl]propionyl}-o-chloro-N-i sopropyl- benzamide) is obtained by reacting an azetidinone derivative expressed by formula II and an imide compound of formula III in the presence of a compound of formula IV (M is a metal atom; Hal is a halogen; R is a lower alkyl, etc.; (n) and (m) are each 0 or 1-5; (n+m) is valence of M) and a base. |
