| 摘要 |
<p>PURPOSE: To obtain a D-mannosamine derivative useful as an intermediate for neuraminic acid by protecting the hydroxyl group of a specific talopyranose compound, treating the protected compound with a base, protecting the produced hydroxyl group, deprotecting the first hydroxyl group, oxidizing the product, treating the oxidation product with hydroxyamine and subsequently reducing the treated product. CONSTITUTION: The method for producing the D-mannosamine deirvative of formula V used as the precursor of D-mannosamine useful as a synthetic intermediate for neuraminic acid comprises protecting the hydroxyl group of 1, 6:3,4- dianhydro-β-D-talopyranose of formula I with a 1-ethoxyethyl group, etc., treating the protected product with a base, protecting the hydroxyl group of the producedβ-D-mannopyranose derivative of formula II (R<2> is the hydroxyl group-protecting group) with a phenylmethyl group, etc., removing the hydroxyl group-protecting group of R<2> from the protected compound, oxidizing the produced compound of formula III (R<1> is the hydroxyl group-protecting group), treating the oxidation product with hydroxyamine or its derivative, and subsequently reducing the produced oxime compound of formula IV.</p> |
