ANTI-INFLAMATIC, ANTI-HISTAMINE AND ANTI-RHEUMATIC AGENTS COMPRISING BIFLAVONOIDS FROM GINKO KEAVES

摘要

The anti-inflamatic, anti-allergic and antirheumatic agent contains sciadopitysins [R1=R2=R4=CH3; R3=H , ginketins [R1=R2=CH3; R3=R4=H , isoginkgetins [R1=R3=H, R2=R4=CH3 , bilobetins [R1=R3=R4=H; R2=CH3 or anentoflavones [R1=R2=R3=R4=H of biflovones of formula(I). The biflavones are obtained by extracting gingko leaves with an methanol, adding a distilled water and a chlorofrom to the methanol extract, shaking and fractionating the mixture, adding an ethylacetate to the fractionated soln. and shaking the mixture, dehydrating the fractionated soln. with an anhydrous mirabilite to obtain a biflavone fractionated soln., and segregating the soln. with 0˜10% CHCl3-MeOH.