| 摘要 |
A water-soluble taxol derivative represented by general formula (II) and different from conventional prodrug type of compounds, (wherein R represents hydrogen or methyl). The water solubility has been improved by introducing a highly polar amino sugar unit into the 7-hydroxy group of taxol by an organic synthetic chemical technique, followed by salt formation. As compared with taxol itself, this derivative has an excellent antitumor activity, an improved water solubility and a reduced toxicity. |
